منابع مشابه
High glucose promotes mesangial cell apoptosis by oxidant-dependent mechanism.
Reactive oxygen species are recognized as important mediators of biological responses. Hyperglycemia promotes the intracellular generation of superoxide anion and hydrogen peroxide. In several cell lines, oxidant stress has been linked to the activation of death programs. Here, we report for the first time that high ambient glucose concentration induces apoptosis in murine and human mesangial c...
متن کاملProstaglandins Hypoxia Enhances Prostaglandin Synthesis in Renal Mesangial Cell Culiures
In view of recent findings which suggest that renal prostaglandins mediate the effect of hypoxia on erythropoietin production, we have studied whether hypoxia is a stimulus for in vitro prostaglandin synthesis. Studies were carried out in rat renal mesangia] cell cultures which produce erythropoietin in an oxygen-dependent manner. Production rates of POE Z and in specified samples also off 6-ke...
متن کاملAngiotensin II-induced mesangial cell apoptosis: role of oxidative stress.
BACKGROUND Angiotensin II (ANG II) has been shown to play a role in the induction of glomerular injury. In the present study, we evaluated the effects of ANG II on mesangial cell apoptosis and the involved molecular mechanism. MATERIALS AND METHODS The effect of ANG II on apoptosis of mouse mesangial cells (MC) was evaluated by morphologic, DNA fragmentation and TUNEL assays. To evaluate the ...
متن کاملMesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis.
Increases in mesangial cell number may herald glomerular scarring, but they are not irreversible. This study sought mechanisms by which surplus glomerular mesangial cells can be cleared. A small proportion of cultured mesangial cells exhibited typical morphological features of apoptosis (programmed cell death), which was increased by growth factor deprivation or exposure to cycloheximide, stimu...
متن کاملIntermittent High Glucose Enhances Apoptosis in INS-1 Cells
To investigate the effect of intermittent high glucose (IHG) and sustained high glucose (SHG) on inducing β-cell apoptosis and the potential involved mechanisms, INS-1 beta cells were incubated for 72 h in the medium containing different glucose concentrations: control (5.5 mmol/L), SHG (33.3 mmol/L), and IHG (5.5 mmol/L and 33.3 mmol/L glucose alternating every 12 h). Cell viability, apoptosis...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2006
ISSN: 0023-6837,1530-0307
DOI: 10.1038/labinvest.3700418